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​​​​​​​EFORT Webinar
CELL-FREE PRODUCTS IN OA:
SECRETOM, EVS AND EXOSOMES

Webinar Chair 
Prof. Laura DE GIROLAMO, PhD | Italy​​​​​​​


​​​​​​​19:00-19:02 | Introduction
Prof. Laura DE GIROLAMO, PhD | Director of REGAIN - REgenerative GAleazzi INstitute | Milan, Italy 

19:02-19:17 | Tiny vesicles, big effect: exploring the basic biology of exosomes 
Dr. Enrico Ragni | Galeazzi Sant'Ambrogio Hospital | Milan - Italy

19:17-19:32 | Impact of cultivation method of mesenchymal stromal cells on the therapeutic efficacy of extracellular vesicles
Prof. Andrea De Luna | Center for Regenerative Medicine, University for Continuing Education Krems | Krems an Der Donau - Austria

19:32-19:47 | Generation EV: inheriting MSC parental potential while avoiding their clinical roadblocks
Prof. Maroun Khoury | Nano-regenerative Laboratory, Biomedical Investigastion and Innovation Center (CiiB)  University de los Andes | Santiago, Chile

19:47-19:58 | Questions and Answers | All Webinar Audience

19:8-20:00 | Final Remarks
Prof. Laura DE GIROLAMO, PhD | Director of REGAIN - REgenerative GAleazzi INstitute | Milan, Italy 
The Next Horizon in Orthobiologics: Moving Beyond the Cell.

Join us for a definitive session bridging the lab bench and the bedside. This webinar will analyse the cutting-edge science and emerging clinical application of cell-free therapeutics for Osteoarthritis (OA)—the most promising area of musculoskeletal regeneration.

The objectives of this Webinar are:
  • Understand Exosome Fundamentals and Mechanisms
    - Explain the basic biology of exosomes ("Tiny vesicles, big effect"), including their origin, composition, and role as key mediators in cell-to-cell communication.
    - Articulate the specific mechanisms by which exosomes exert their therapeutic effects (e.g., anti-inflammatory, regenerative) in the context of joint disease.
  • Analyze Production and Potency Factors
    - Evaluate the significant impact of mesenchymal stromal cell (MSC) cultivation methods on the quantity, quality, and resultant therapeutic efficacy of their derived Extracellular Vesicles (EVs).
    - Identify the critical production variables that researchers and developers must control to ensure consistent and potent cell-free OA biotherapeutics.
  • Assess Clinical and Safety Data
    - Appraise the current scientific and clinical evidence regarding the safety and efficacy of exosome biotherapeutics specifically for the treatment of joint disease.
    - Discuss the major challenges and considerations necessary for the clinical translation of exosome-based therapies, including regulatory pathways and safety monitoring in patients.

Duration: 60 minutes

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This Webinar is organised by EFORT independent of any commercial educational support. ​​​​You can view it from your computer, tablet or mobile phone.

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https://www.efort.org/webinars​​​​​

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